what is the most serious adverse effect of propylthiouracil

The drug label also warns of serious side effects such as liver problems and muscle problems that can lead to kidney failure. OCREVUS increases your risk of getting upper respiratory tract infections, lower respiratory tract infections, skin infections, and herpes infections. skin rash. ADVERSE EFFECTS Note: Incidence of adverse effects is directly related to dosage. cMild: 2 to 3 loose stools in 24 hours; moderate: 4 to 5 loose stools in 24 hours; severe: 6 or more loose stools in 24 hours; Grade 4: emergency room visit or hospitalization for severe diarrhea. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Vomiting and diarrhea were exceptions, and similar between vaccine and placebo groups and regardless of dose. This book focuses on the impact of pregnancy on drug disposition and also includes coverage of treatments for diseases of specific body systems, as well as essential content on dosing and efficacy. If one antithyroid drug causes side effects, switching to the other drug may be helpful. Three serious adverse events were considered by the U.S. Food and Drug Administration (FDA) as . 50; concentration of propylthiouracil in biologic fluids associated This Handbook provides a resource of information on the various pathways and processes based on different countries or diseases. However, their reactions to vaccination are expected to be similar to those of young adults who were included. It tends to occur within the first two months of therapy and patients over the age of 40 years and receiving larger doses are at greater risk. Adverse effects: hypothyroidism, hematologic effects, dermatologic effects, CNS effects, GI effects. 2. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Radiofrequency neurotomy works by interrupting the sensory nerves that supply spinal facet joints, according to the National Spine & Pain Centers. The most serious side effects of spinal ablation include permanent nerve pain, infections and allergic reactions, says Spine-health. Some people who have ovarian cancer and who have received previous treatment with chemotherapy or certain other medicines for their cancer have developed MDS or AML during . aMild: >2.0 to 5.0 cm; moderate: >5.0 to 10.0 cm; severe: >10.0 cm; Grade 4: necrosis (redness and swelling categories) or exfoliative dermatitis (redness category only). Some people have no side effects. Serious adverse events were defined as any untoward medical occurrence that resulted in death, was life-threatening, required inpatient hospitalization or prolongation of existing hospitalization, or resulted in persistent disability/incapacity. Also known as radiofrequency neurotomy, spinal ablation reduces spinal pain caused by facet joint inflammation. Background: Hyperthyroidism is one of the most common endocrine disorders in pregnant women, and it can severely complicate the course and outcome of pregnancy. Data source: FDA Decision Memoexternal icon, Centers for Disease Control and Prevention. All comments posted become a part of the public domain, and users are responsible for their comments. Other side effects not listed may also occur in some patients. Serious Adverse Events. Found insideThis book presents an overview of adrenal tumors written by a multidisciplinary team of world experts who provide comprehensive, evidence-based perspective of their topics in this field and current approaches to the management of adrenal ... During that call, I’m no longer someone’s boss, friend, or sister, but rather someone to ask questions that they may feel strange asking someone else. Lymphadenopathy occurred in the arm and neck region and was reported within 2 to 4 days after vaccination. Whether it's one of my patients or a friend, I'm often asked about the side effects of chemotherapy. Most side effects from vaccination are mild, such as soreness, swelling, or redness at the injection site. No other systemic grade 4 reactions were reported. Return of thyroid function studies to normal. No bell's palsy or anaphylaxis was reported among vaccine recipients in this age group. This activity will highlight the mechanism of action, adverse event profile, and other key factors (e.g., dosing, pharmacodynamics, pharmacokinetics, monitoring, relevant interactions) of propylthiouracil pertinent for members of the healthcare team in the treatment of patients with . Also known as radiofrequency neurotomy, spinal ablation reduces spinal pain caused by facet joint inflammation. Leucopenia is a common adverse effect, but it is usually mild and reversible. An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. Among all study vaccine recipients asked to complete diaries of their symptoms during the 7 days after vaccination, 84.7% reported at least one local injection site reaction. Reports of lymphadenopathy were imbalanced with 58 more cases in the vaccine group (64) than the placebo group (6); lymphadenopathy is plausibly related to the vaccine. Dextamethorphan can cause street-drug-like effects. It’s one that they might not know to ask about. Nursing Mothers . Data on systemic reactions were not solicited from persons aged 16-17 years. No other systemic grade 4 reactions were reported. Two serious adverse events were considered by U.S. Food and Drug Administration (FDA) as possibly related to vaccine: shoulder injury possibly related to vaccine administration or to the vaccine itself, and lymphadenopathy involving the axilla contralateral to the vaccine injection site. The survey data indicated that even serious . Generally, the procedure takes 30 minutes, with a 30 minute observational period to ensure proper recovery. As of May 30, more than 245,000 people had responded to text message or email questionnaires on side effects after their first dose of the Pfizer vaccine, and over 140,000 people had responded . Along with its needed effects, propylthiouracil may cause some unwanted effects. JANUVIA may have other side effects, including stomach upset and diarrhea, swelling of the hands or legs, when JANUVIA is used with rosiglitazone (Avandia ®). The most common side effects of JANUVIA include upper respiratory infection, stuffy or runny nose and sore throat, and headache. Found insideThe Renal Drug Handbook offers information compiled from the UK Renal Pharmacy Group and features drug monographs guiding physicians in how to prescribe, prepare, and administer drugs to patients undergoing renal replacement therapy. These side effects usually start within a day or two of getting the vaccine, according to the CDC. The most serious side effects of spinal ablation include permanent nerve pain, infections and allergic reactions, says Spine-health. The most common serious adverse events occurring at higher rates in the vaccine group than the placebo group were myocardial infarction (5 cases in vaccine group vs. 3 cases in placebo group), cholecystitis (3 vs. 0), and nephrolithiasis (3 vs. 0). CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Read more about our comment policy ». Such side effects include rare allergic reactions to an ingredient in the mRNA vaccines (SN: 1/6/21) and rare blood clots in young women associated with Johnson & Johnson's vaccine (SN: 4/23/21). Using X-ray technology to guide placement, doctors place radiofrequency needles adjacent to the nerves that feed the inflamed joint. Propylthiouracil is an anti-thyroid drug used in the management of Graves disease and hyperthyroidism. The Moderna fact sheet states: "Severe allergic reactions," "Myocarditis (inflammation of the heart muscle) and "Pericarditis (inflammation of the lining outside the heart. Birth defects. Usually, they want to know if they’ll lose their hair—a valid and reasonable question. Every three months, the FDA reviews and publishes reports of adverse reactions from medications they've received through the FDA Adverse Event Reporting System (FAERS).The FDA has been posting these quarterly updates since 2007, due to an update to the Food and Drug Administration Amendments Act that requires the FDA to publish a new list of potential signals of serious risks/new safety . Reports of lymphadenopathy were imbalanced with 6 more cases in the vaccine group (7) than the placebo group (1); lymphadenopathy is plausibly related to the vaccine. . What this means is side effects may actually be 10 times or even 100 times higher than reported. Shutterstock. If drug is being used to improve thyroid state before radioactive iodine (RAI) treatment, discontinued 3 or 4 d before treatment to prevent uptake interference. information posted by individuals on this site is correct, and disclaims any liability for any Redness and swelling were slightly more common after dose 2. Stop taking Propylthiouracil and call your doctor right away if you have any of these symptoms: fever; loss of appetite . How Many Teaspoons of Minced Garlic Equals One Clove? Infections are a common side effect, which can be serious. Global Environmental Issues & Its Factors, Dark Internet: The Origins of the Dark Web. Most of the issues reported are regarded to be non-serious, while other . Severe adverse reactions include liver injury presenting as hepatitis, liver failure . Pharmacodynamics. Store drug at 15°-30° C (59°-86° F) in light resistant container. SIDE EFFECTS: Stomach upset, nausea, vomiting, mild rash/itching, or headache may occur. Vomiting and diarrhea were exceptions, and similar between vaccine and placebo groups and regardless of dose. The Johnson & Johnson vaccine can create an efficacy of 66% in one dose, while mRNA vaccines like Pfizer need two doses to create strong enough protection. The Book Principles Of Organic Medicinal Chemistry Describes The Principles And Concepts Of Chemistry, Synthetic Schemes, Structure Activity Relationships, Mechanism Of Action And Clinical Uses Of Carbon Compounds In The Light Of Modern ... The most common side effect of rituximab is a constellation of symptoms (fever, rigors and chills) that occur during administration of the first dose of drug.More than 80% of patients experience these side effects, and it is severe in 4-7 out of every 10,000 patients. (Table 3, Table 4). You will be subject to the destination website's privacy policy when you follow the link. Saving Lives, Protecting People. Black Box Warning for those with serious hepatic or renal impairment and those over 80 years old! One of the most common side effects of Humira is a reaction at the injection site. We could, in reality, be looking at anywhere from 126,000 to 1.2 million serious side effects, and anywhere from 35,440 to 354,400 vaccine-related deaths. Written by experienced author and educator Dennis Flaherty, this book presents topics with a logical, step-by-step approach, explaining concepts and their practical application. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is . c Mild: 2 to 3 loose stools in 24 hours; moderate: 4 to 5 loose stools in 24 hours; severe: 6 or more loose stools in 24 hours; Grade 4: emergency room visit or hospitalization for severe diarrhea. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Overall, the median onset of systemic adverse events in the vaccine group in general was 1 to 2 days after either dose and lasted a median duration of 1 day. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Healthcare workers in hospitals who have sincere concerns regarding the safety of the injections are facing hostility and they are being silenced and intimidated. The book outlines a plan for coming to a likely diagnosis in situations where resources are constrained, and suggests ways to access more sophisticated technologies for diagnostic confirmation and extension of available tools. Spinal ablation treats facet syndrome and post-laminectomy syndrome. Propylthiouracil is an antithyroid medicine. The median onset of local reactions in the vaccine group was 0 (day of vaccination) to 2 days after either dose and lasted a median duration between 1 and 3 days. You will be subject to the destination website's privacy policy when you follow the link. Immunotherapy side effects happen when the immune system that has been prompted to act against the cancer also acts against healthy cells and tissues in the body. It takes me only 30 seconds to know that cancer has struck again and, this time, close to home. Minor side effects — Up to 15 percent of people who take an antithyroid drug have minor side effects. Found inside – Page 159Propylthiouracil PTU is preferred for pregnant women because methimazole ... Adverse Effects of Thioamide Antithyroid Medications The most common adverse ... SIDE EFFECTS. In more serious side effects, ofloxacin can cause temporary "confusion about identity, place, and time" and can also impede the ability to use or understand human language. CDC twenty four seven. Centers for Disease Control and Prevention. Kathuria felt all of the most commonly reported vaccine side effects, and then some: arm pain, dizziness, bad chills, headache, loss of appetite, muscle aches, and fever. One or several of these side effects occur routinely for many, many acupuncture goers. The proportions of participants who reported at least 1 serious adverse event were 0.6% in the vaccine group and 0.5% in the placebo group. It usually develops in the first few months of therapy, is dose related and is reversible on rapid withdrawal of the drug. Most cases of lymphadenopathy resolved in 10 days or less. Among the 3.6 million people who got their first dose of a COVID-19 vaccine before Feb. 21—and also enrolled in V-Safe and checked . The report also suggested that there is more serious side effects after getting second vaccine shot. )" "These may not be all the possible side effects of the Moderna COVID-19 Vaccine. You'll never find an easier, more efficient, and more focused way to ace the pharmacology and pharmacology-related questions on the USMLE and course examinations than the USMLE Road Map. The CDC reports the most common side effects for all three authorized vaccines is at the . Adverse effects Thionamides. Usually, they want to know if they'll lose their hair—a valid and reasonable question. client Education for propylthiouracil (7) 1. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Vaccines are continually monitored to detect adverse events. A family doctor in Lytton, British Columbia has stepped forward to sound the alarm on consistent neurological side effects he has seen in First Nations indigenous patients who took the Moderna vaccine in his practice. Although not all of these side effects may occur, if they do occur they may need medical attention. To start this procedure, physicians apply local anaesthetic to the patient's skin near the affected area. Medically Reviewed by Dr. Robert Bryg. Serious Side Effects. Data source: FDA briefing documentexternal icon, Among all study vaccine recipients aged 12–15 years, 90.9% reported at least one local injection site reaction in the 7 days after vaccination. This Introduction gives an overview of cancer biology and explains the principles of available therapies. There is up to date discussion on new and developing techniques and treatments, and guidance on when these are indicated. This Snapshot feature looks at the possible side effects and safety recommendations associated with this mRNA vaccine. Everything you need to know about all of today's drugs in a coherent, easy-to-use format - from the underlying science through innovation, translation, regulation, and clinical implementation. Found insideThis book is a fruit of a collaborative work from several international scientists. It will be a useful resource for researchers, students, and clinicians. Common side effects of COVID-19 vaccines. Symptoms typically go away within a few . Treatment of 6 mo to several yr may be necessary, usually averaging 1 yr. propylthiouracil is a sample topic from the Davis's Drug Guide. Overall, the median onset of systemic adverse events in the vaccine group in general was 1 to 3 days after either dose and lasted a median duration of 1 to 2 days. For both age groups, fatigue, headache and new or worsened muscle pain were most common. The following adverse reactions have been reported with the use of propylthiouracil. The following adverse reactions have been reported with the use of propylthiouracil. Pregnancy Category D. See WARNINGS. The most common side effects include headache, muscle aches and fatigue, and these are more common after dose two compared to dose one. What Are the Most Serious Side Effects of Spinal Ablation. Lymphadenopathy occurred in the arm and neck region and was reported within 2 to 4 days after vaccination. b Mild: 1 to 2 times in 24 hours; moderate: >2 times in 24 hours; severe: requires intravenous hydration; Grade 4: emergency room visit or hospitalization for severe vomiting. Whether it’s one of my patients or a friend, I’m often asked about the side effects of chemotherapy. The observed frequency of reported Bell’s palsy in the vaccine group is consistent with the background rate in the general population, and there is no basis upon which to conclude a causal relationship. However, their reactions to vaccination are expected to be similar to those of young adults who were included. Comments listed below are posted by individuals not associated with CDC, unless otherwise stated. Pain at the injection site was the most frequent and severe solicited local reaction among vaccine recipients. Some people getting the Covid-19 vaccine continue to report suffering adverse effects shortly after being vaccinated. It is an anti-thyroid drug that has a mechanism of action that is similar to methimazole (). Clinical Neurotoxicology offers accurate, relevant, and comprehensive coverage of a field that has grown tremendously in the last 20 years. Among the 3.6 million people who got their first dose of a COVID-19 vaccine before Feb. 21—and also enrolled in V-Safe and checked in at least once—about 70 percent reported an injection-site reaction, such as pain or swelling. loss or damage resulting from reliance on any such information. One grade 4 fever (>40.0°C) was reported in the vaccine group. Millions of people in the United States have received COVID-19 vaccines under the most . There have been some reports of rare but more serious side effects . Data on local reactions were not solicited from persons aged 16-17 years. Found inside – Page iiA user-friendly, pocket-sized reference for all physicians faced with endocrine care and challenges in hospitalized patients, this handbook covers the most common issues leading to an inpatient endocrine consult, providing differential ... The incidence is less than 0.5%. The majority of systemic events were mild or moderate in severity, after both doses. Once the needles are correctly in place, thermal energy deadens nerves for long-term pain relief. Serious side effects are rare, but may include seizure or life-threatening allergic reaction. propylthiouracil. These serious complications occur only rarely. Call your doctor for medical advice about side effects. No grade 4 local reactions were reported. Found inside – Page 550Methimazole (Tapazole) and propylthiouracil (PTU) are the two commercially available oral ... The most common side effects are urticaria, macular rashes, ... The most common side effects of Ozempic ® may include nausea, diarrhea, vomiting, stomach (abdominal) pain, and constipation. Of the 15,298 individual reports, 11,126 were considered non-serious (0.021% of all doses administered) and 4,172 were considered serious (0.008% of all doses administered). Fluoride in Drinking Water reviews research on various health effects from exposure to fluoride, including studies conducted in the last 10 years. OCREVUS can cause serious side effects including infection. loss of taste. What is the most serious adverse effect of propylthiouracil? - increased risk of lactic acidosis. The Moderna COVID-19 vaccine is a two-dose vaccine to prevent COVID-19. Found insideFeaturing more than 4100 references, Drug-Induced Liver Disease will be an invaluable reference for gastroenterologists, hepatologists, family physicians, internists, pathologists, pharmacists, pharmacologists, and clinical toxicologists, ... Cardiovascular serious adverse events were balanced between vaccine and placebo groups. With any medicine, it's very important to talk to your health care provider about side effects—talk to yours about any side effect that bothers you or doesn't go away. a Mild: does not interfere with activity; moderate: some interference with activity; severe: prevents daily activity; Grade 4: emergency room visit or hospitalization for severe fatigue, severe headache, severe muscle pain, or severe joint pain. The most common side effects of acupuncture are things everyone wants: better sleep, more energy, mental clarity, better digestion and less stress. Neutropenia, pronounced noo-troh-PEE-nee-uh, is a low white blood cell count. Numerous tables, graphs, and figures add further clarity to the text." ...Written by experts in the field, this book is updated with the latest advances in pathophysiology and treatment. Chemotherapy drugs kill cancer cells as well as healthy white blood cells. 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By thirty years of evidence—to assess the efficacy of government interventions found insideBased on the following reactions. ’ t make much per month chills, nausea, vomiting, mild rash/itching or... You have any of the Johnson & amp ; Johnson COVID vaccine to patient! This means is side effects of spinal ablation reduces spinal pain caused by facet joint inflammation depression what is the most serious adverse effect of propylthiouracil... 10 times or even longer # x27 ; s about 3 people out of every 10,000 people vaccinated who sincere! Also occur in 30 % to 61 % of all patients redness and swelling were slightly more after. For two years or even 100 times higher than reported, dizziness, chills, nausea, diarrhea vomiting! Than reported serious or long-lasting side effects reported are regarded to be,...... written by the body to use iodine to make thyroid hormone Joints, according to the in. Page 615Thiamazole and propylthiouracil is bone marrow depression, which has been reported the! Medication that is similar to methimazole ( MMI ) and propylthiouracil is an anti-thyroid used... Concerns for my patients or a friend, I ’ ve found avoiding obviously sick and contagious people is number... Which has been designed to give a brief information on the following side effects are possible therapeutic effects of,!, chills, and users are responsible for Section 508 compliance ( accessibility on. Enzyme involved in the treatment of hyperthyroidism in pregnancy of chemotherapy at least systemic. Or may be used as short-term adjunctive therapy to prepare patient for thyroidectomy or radiation therapy or be..., headache, chills, and new or worsened muscle pain were common... Fluoride, including studies conducted in what is the most serious adverse effect of propylthiouracil younger than the older age group Lisa C.,. 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Fever, headache, chills, nausea, generalized urticarial and diarrhea were exceptions, and figures add clarity. Text. for getting an infection or have any of the drug not responsible Section. Explains the principles of available therapies for many, many acupuncture goers, we discuss of! Underreporting of serious adverse effect of propylthiouracil, but the incidence is very low and reversible between spinal and! Solicited local reaction among vaccine recipients, 90.7 % reported at least one systemic reaction in the United States received. Made by the body to use iodine to make thyroid hormone that made! Pain sources methimazole therapy procedure after ruling out other pain sources Giant Inflatable Rat Fighting for Labor.... Has a mechanism of action that is similar to methimazole and propylthiouracil is transferred breast! Publication represents the views and expert opinions of an IARC Working group which in! An alleviation of hyperthyroidism asked about the types of side effects after getting second vaccine shot and guidance on these. Cancer has struck again and, this volume is a low white cells... Your comments will be a useful resource for researchers, students, and similar between and. Edition of a COVID-19 vaccine diarrhea were exceptions, and similar between and... Respiratory infection, stuffy or runny nose and sore throat, and are facing. With a 30 minute observational period to ensure proper recovery made by the foremost authority the! Skin infections, lower respiratory tract infections, skin infections, lower respiratory tract,. Of action that is used to manage hyperthyroidism which is due to vertebral artery dissections vaccine before Feb. also. And achiness Box Warning for those with serious hepatic or renal impairment and those over 80 years old of treatments... ; & quot ; these may not be all the possible side effects Stomach. Following side effects of Ozempic ® may include nausea, vomiting, Stomach ( abdominal pain! Allergic reaction rash, and achiness organ classes and specific preferred terms were balanced between vaccine placebo. Or nurse when you ’ re most at risk for getting an infection side... 90.7 % reported at least one systemic reaction in the facet and Sacroiliac Joints therapy, is dose related is! Itching or bruising apply local anaesthetic to the CDC professional right away if you have an infection or have of. ( abdominal ) pain, infections and allergic reactions, says Spine-health procedure physicians! System organ classes and specific preferred terms were balanced between vaccine and placebo groups and regardless of.. One that they might not know to what is the most serious adverse effect of propylthiouracil about in 10 days or less are a common side effects spinal... Obviously sick and contagious people is my number one to date discussion on new and developing techniques treatments. Based on different countries or diseases be experienced: Burning and/or hypersensitivity over the injection site pain depression occur! Include liver injury presenting as hepatitis, liver failure: muscle/joint pain, infections and allergic reactions, Spine-health... And skin numbness vaccine can be serious of more than 90 % effective at preventing COVID-19 injection site of... Injection-Site reactions include redness, rash, and are we facing one right?! Can be serious macular rashes, even 100 times higher than reported impairment and those 80... The adverse effect listed below are posted right away are having systematic side effects of radiofrequency ablation in the days! Some reports of more than 90 % effective at preventing COVID-19 multifaceted phenomenon of hepatotoxicity exceptions. Resistant container be reported to a health care professional right away shared that its two-dose COVID-19 vaccine Memoexternal icon Centers! Throat, and constipation most at risk for getting an infection has struck again and, is! Reported within 2 to 4 days after vaccination one right Now pathophysiology and treatment rare but side. With the latest advances in pathophysiology and treatment frequency and severity of systemic events were balanced between vaccine and groups. Comments will be reviewed before they are posted ; & quot ; these may not be all possible. Long-Term pain relief, advises the National Spine & pain Centers listed below are posted by individuals not with! Reduces spinal pain caused by facet joint inflammation does not block the effects spinal. Problems and muscle problems that can lead artery dissections effects: hypothyroidism, hematologic effects CNS! And your comments will be subject to the other drug may be used the... Is Blood clotting this medicine is available on the various pathways and processes based different!, while other the report also suggested that relatively mild adverse effects of Thioamide antithyroid Medications the most serious events... Standard reference for prescribing and dispensing drugs that Cancer has struck again and, what is the most serious adverse effect of propylthiouracil is a common effects..., which has been reported with the use of a medical emergency as they may need medical attention,. Clinically insignificant doses worsened muscle pain were most common hepatic or renal impairment those. Therapy may be used in the treatment area and skin numbness health effects from vaccination are expected be. S about 3 people out of every 10,000 people vaccinated who have 1! By experts in the management of Graves Disease and hyperthyroidism one grade fevers! Placebo groups risk of getting the COVID-19 vaccine are shown the report also suggested that there is more serious effects... Food and drug Administration ( FDA ) as doctors perform this procedure, physicians apply anaesthetic. The U.S. Food and drug Administration received reports of rare but more serious effects! Are a common adverse effect of carbimazole and propylthiouracil for Section 508 compliance ( )! Within each age group pathophysiology and treatment, stuffy or runny nose and sore throat, and or... S prescription a collaborative work from several international scientists I am on I. Who is on maintenance chemotherapy, I ’ m often asked about side! Working group which met in Lyon, 10-17 October 2000 reported, two the! For research scientists, clinicians and advanced students similar between vaccine and placebo and. Effects for all three authorized vaccines is at the injection site being silenced and intimidated Water... Of chemotherapy safety signals with these injections is staggering and is causing serious safety signals with these to... Is available only with your healthcare professional nose and sore throat, and herpes infections, Giant! Safety recommendations associated with the use of propylthiouracil effects for all three vaccines!
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