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Publication: Clin Infect Dis 2002 Oct 1;35(7):851-858. Evidence indicates that this vaccine is effective in preventing cutaneous and inhalational anthrax; ... Local and state health departments should he notified also and be ready to provide any public health management and follow-up that may be needed.

Use doxycycline or any quinolone (eg, ciprofloxacin, levofloxacin) for postexposure prophylaxis (PEP) to prevent inhalational anthrax.

If someone has symptoms of anthrax, it’s important to get medical care as quickly as possible to have the best chances of a full recovery. Anthrax sepsis – develops after the lymphohematogenous spread of B. anthracis from primary lesion. Oral antibiotic should be dosed according to guidelines for postexposure prophylaxis.>50 kg: 500 mg every 24 hoursAmoxicillin 1 g every 8 hours (susceptible strain only)Moxifloxacin 400 mg every 24 hoursPathogenic to laboratory animalsRifampin 20 mg/kg per day divided every 12 hours (max 300 mg/dose)Edema toxin + lethal toxin = Inhibited PMN function and phagocytosisLinezolid 600 mg every 12 hours< 12 years: 30 mg/kg/day divided every 8 hoursThree doses of vaccine should be administered during the 4-week period (at 0, 2, and 4 weeks post exposure). All patients with suspected systemic illness should be admitted to inpatient for treatment. In severely ill patients, 200 mg IV/PO every 12 hours may be continued (without toxicity) for the duration of therapy. Another eleven patients had cutaneous anthrax. See also: Full article as HTML • PDF.

Your doctor will first want to rule out other, more common conditions that may be causing your signs and symptoms, such as flu (influenza) or pneumonia. They may require aggressive treatment, such as continuous fluid drainage and … The preferred agent used to treat nonbioterrorist anthrax is penicillin. Thereafter, patients should complete a 60-day course of antibiotics with oral monotherapy to prevent relapse involving dormant endospores.

Publisher: Oxford University Press. This disease is caused by gram positive bacilli called bacterium bacillus anthracis. If risk of exposure is considerable, initiate PEP.Usually ferments salicin rapidly< 45 kg: 4.4 mg/kg loading dose (max 200 mg) followed by 4.4 mg/kg/day divided every 12 hours (max 100 mg/dose)In patients with suspected or confirmed anthrax meningitis, if not already done, a lumbar puncture should be performed for CSF analysis.
After anthrax toxins have been released in the body, one possible treatment is antitoxin. Use any quinolone in patients who are unable to take penicillin or doxycycline.Rifampin 20 mg/kg/day divided every 12 hours (max dose, 300 mg/dose)Amoxicillin 75 mg/kg/day divided every 8 hours (max dose, 1 g/dose)Ciprofloxacin 400 mg every 8 hoursFerments salicin slowly or not at allDoxycycline 100 mg every 12 hoursCiprofloxacin 30 mg/kg/day divided every 12 hours (max dose, 500 mg/dose)Disclosure: Nothing to disclose.Anticipate a therapy duration of at least three weeks or until clinical improvement, whichever comes last, as clinical improvement may take several weeks.

4) Persons who may have been exposed to anthrax are not contagious, so quarantine is not appropriate. Cutaneous anthrax, the most common type, occurs after bacteria or spores enter the skin through a cut or abrasion.

Patients with serious cases of anthrax will need to be hospitalized. No human studies are available that document efficacy of available vaccines.Nonpathogenic to laboratory animalsDoxycycline 200-mg loading dose followed by 100 mg every 12 hoursGrowth in gelatin absent or resembles atypical fir treeFor adults with systemic anthrax (inhalational, intestinal, meningitis, injection), the CDC expert panel recommends the following:Age 12-17 years, ≥45 kg: 400 mg every 24 hoursVancomycin 60 mg/kg/day divided every 8 hours (max 2 g/dose); target trough, 15-20 mcg/mLClindamycin 40 mg/kg/day divided every 8 hours (max 900 mg/dose)Age 12-17 years, < 45 kg: 8 mg/kg/day divided every 12 hoursThe emergency department workup includes rapid initiation of intravenous antibiotic therapy. Skin testing.

Inhalational anthrax: epidemiology, diagnosis, and management.
2. Shafazand S(1), Doyle R, Ruoss S, Weinacker A, Raffin TA.

MMWR Morb Mortal Wkly Rep 2001 ;50: 909 - 919 Medline Author information: (1)Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University Medical Center, Stanford, CA 94305-5236, USA. Clindamycin may be added for its anti-exotoxin effect. The incubation period ranged from 1 to 10 days.