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The Cell and Molecular Biology Graduate Group (CAMB) is an interdisciplinary graduate program, providing rigorous training in modern cell and molecular biology. Her lab employs a novel series of HSP70 inhibitors for melanoma and colorectal cancer therapy.Ira Brind Professor and Program Leader, Molecular & Cellular Oncogenesis Program, The Wistar Institute Cancer CenterLuis J. Montaner, D.V.M., D.Phil.Herbert Kean, M.D., Family Endowed Chair Professor; Director, HIV-1 Immunopathogenesis Laboratory and Leader, HIV Research Program, Vaccine & Immunotherapy Center;

Maureen Murphy, PhD (Wistar) Professor & Program Leader, Molecular & Cellular Oncogenesis Program; Scientific Director, Histotechnology Facility; Associate Vice President, Faculty Affairs Wistar Institute

From a screen, I have identified several hnRNPs that upregulate HbF expression when knocked down. Cardiac myocytes are unique in their constant and cyclic exposure to mechanical forces as the heart beats. Work in the Murphy lab also aims to identify novel cancer therapies that are more effective on tumors that contain genetic variants of p53 that exist in African Americans and Ashkenazi Jewish populations, in order to improve personalized medicine.p53 is the most important gene in human cancer. The Genetics and Epigenetics program provides students an opportunity to undertake concentrated study in the areas of model organism genetics, human genetics, transcriptional and post-transcriptional gene regulation, epigenetics, genomics and bioinformatics. Exposure to Selection Team members who may be interested in supporting the technologies in the future is an additional benefit.Funding and business advice to help academic researchers commercialize promising technologiesParticipating projects are evaluated for funding based on the following criteria:A team of nurses and engineers at the University of Delaware is revolutionizing training of healthcare workers, starting with techniques for emergency airway management, by developing new mannequin simulation tools.A team at Pennsylvania State University is using proteins to coat the surfaces of biomedical swabs, allowing them to capture DNA for analysis from even tiny amounts of blood or other biological samples.Each uniquely designed milestone-driven proof-of-concept plan answers key questions to guide the Investigator as s/he seeks follow on funding from public or private sources.If your organization is not a current partner, and would like to participate in the program, please contact us at qed [at] sciencecenter.org.A team at Rutgers University is developing a technology for programming stem cells for use in therapies in people with incurable and debilitating diseases and disorders.The involvement of industry licensing and investment professionals in the selection of projects for funding is an integral component of the QED Program.
Altered cellular metabolism that promotes tumor growth represents a common feature in HCC.

It shares structural similarities with amyloid plaques that cause degenerative disease. .Sometimes an idea alone is not enough. My thesis project incorporates the usage of established mouse models of lung cancer and cancer cell lines to dissect the mechanisms behind the pleiotropic tumor suppressive programs mediated by p53.My thesis project is about understanding the role that zinc finger proteins play in regulating cell type specific heterochromatin.

More recently, we discovered that a significant fraction of HSP70 in tumors is localized to mitochondria. The Murphy lab uses a series of novel HSP70 inhibitors they have created for the therapy of human tumors, with focus on colorectal cancer and melanoma. The Science Center kickstarts this process by funding up to four projects from each round.The projects selected to participate in the program receive:The QED Program is administered through the Technology Transfer Office of each partner research organization (listed below). However, it is not known exactly how p53 mediates its pleiotropic effects.

Access all our content for $20/month.Please complete the consent form before proceeding.In 1998, Murphy became an Assistant Professor at Fox Chase Cancer Center, where she was promoted to Associate Professor in 2003, and Full Professor in 2011. }, year = {1999}} Graduate Group Affiliations Cell and Molecular Biology; Biochemistry and Molecular Biophysics; Contact information.